APC degrades the complex that makes thrombin; SerpinPC inhibits APC, allowing prothrombinase more time to make thrombin.
How SerpinPC inhibits APC. APC recognises the RCL of SerpinPC as a substrate (middle). During the cleavage of the scissile bond, APC is translocated to the opposite pole of SerpinPC and inactivated through conformational disruption. The final covalent complex (right) is rapidly cleared by the liver.
Hemostasis is a dynamic process involving procoagulant and anticoagulant factors operating simultaneously to detect and repair damage to the vascular endothelium, and to prevent inappropriate clot formation. Perturbations affecting this balance cause bleeding or thrombosis, because of insufficient or excessive formation of the enzyme thrombin....Article PDF